【摘要】 目的 :观察国产草酸铂 (L OHP)联合氟尿嘧啶 (5 FU)、甲酰四氢叶酸钙 (CF)治疗晚期胃癌、大肠癌的疗效。方法 :LFP方案L OHP 130mg m2 ,静脉滴入 ,d1 ;CF 10 0mg m2 ,静脉滴入 ,d1 ～d5;5 FU5 0 0mg m2 ,静脉滴入 ,4～ 6h ,d1 ～d5(5 FU后用 ) ,2 1d为 1个周期。结果 :全组CR 1例 ,PR 12例 ,SD14例 ,PD 5例 ,总有效率 4 0 6 %。初治有效率 4 5 4 % ,复治有效率 38 1% ;胃癌与大肠癌有效率分别为4 1 7%和 37 5 %。主要不良反应为消化道反应及外周神经毒性。结论 :L OHP联合 5 FU、CF方案疗效肯定 ,经济实用 ,毒性可耐受更多还原

【Abstract】 Objective To evaluate the efficacy and toxicity of home made oxaliplatin plus fluoriouracil,and folinic acid combination therapy in the treatment of advanced gastric carcinoma and colorectal carcinoma.Methods Thirty two cases received oxaliplatin 130 mg/m 2,d 1;folinic acid 100 mg/m 2,d 1-d 5 and fluoriouracil 500 mg/m 2,d 1-d 5.The regiment was repeated every 21 days.Results There were 1 CR,12 PR,14 SD and 5 PD in the group.The overall response rate was 40 6%.The major toxic reactions were nausea,vomiting and peripheral neurotoxicity.Conclusions Osaliplatin plus fluoriouracil and folinic acid combination therapy is positively effective and cheap in gastric carcinoma and colorectal carcinoma.The toxicity is mild to moderate and reversible. China J Cancer Prev Treat,2003,10(5):516-517更多还原