【摘要】 目的 :探讨HBV感染所致的急性肝炎、慢性肝炎、肝炎肝硬化患者的细胞免疫能力的改变 ,以期从免疫角度了解该病的发病机理 ,防止病情进一步恶化 ;方法 :测定经临床确诊的急性肝炎 3 5例、慢性肝炎轻度 41例、中度 3 8例、重度 2 5例、肝炎肝硬化 3 7例及 3 0例正常人的T淋巴细胞亚群、白细胞介素 -2 (IL -2 )、可溶性白细胞介素 -2受体 (sIL -2R)的水平 ;结果 :乙型肝炎患者CD3、CD4、CD4/CD8、IL -2水平明显降低 ,CD8、sIL -2R水平明显增高 ,与正常对照比较有显著性差异 (P <0 .0 1 ) ;结论 :乙型肝炎患者细胞免疫功能严重受损 ,发生紊乱。监测细胞免疫功能 ,对判断病情发展、合理选择治疗方案具有指导意义更多还原

【Abstract】 Objective:To study the effects of cellular immunity on the pathogenesis of hepatitis B.Methods:A total of 206 subjects were divided into test group such as acute hepatitis group(n=35), mild chronic hepatitis(n=41), moderate chronic hepatitis(n=38), severe chronic hepatitis(n=25),posthepatitic cirrohis group(n=37), and the healthy subjects served as the normal control group(n=30). The level of T lymphocyte subpopulation, IL-2 and sIL-2R were detected respectively in all groups’serum.Results:The level of CD 3?CD 4?CD 4/CD 8 and IL-2 of the experimental groups were significantly lower than that in control(P<0.01 or P<0.05), while those of CD 8 and sIL-2R were significantly higher than those in control(P<0.01).Conclusion:There were destroy and imbalance of cellular immunity of hepatitis B, and test of cellular immunity was effective to judge the clinical development and select the efficient treatment plan.更多还原