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晚期胰腺癌立体定向放射配合健择治疗疗效观察

Clinical analysis of stereotactic radiotherapy combined with Gemzar for treatment of advanced pancreatic cancer

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【作者】 章晓梅程玉峰吕惠兰程孝国李烿烿

【Author】 ZHANG Xiao-mei,CHENG Yu-feng,L Hui-lan,CHENG Xiao-guo,LI Rong-rong Department of Radiation Oncology,Qilu Hospital of Shandong University(Jinan 250012,China)

【机构】 山东大学齐鲁医院放疗科山东大学齐鲁医院放疗科 山东济南250012山东济南250012山东济南250012

【摘要】 目的 :观察立体定向放射治疗与健择化疗相结合 ,治疗不能手术的晚期胰腺癌的疗效。方法 :13例晚期胰腺癌健择 10 0 0mg/m2 ,2 8d为 1周期 ,在第 1,8,15天给药 ,治疗 2周期。化疗第 2天行立体定向放射治疗 ,分割剂量 5~ 7GY ,每周 3次 ,分 5~ 8次完成 ,DT4 0~ 4 8Gy。结果 :13例随诊 1年以上 ,症状减轻 ,6个月CT检查 ,CR 2例 ,PR 8例 ,NC 2例 ,PD 1例。中位生存期 12个月。结论 :立体定向放射治疗与健择化疗相结合 ,对晚期胰腺癌的治疗有重要价值

【Abstract】 Objective: To observe the efficacy of stereotactic radiotherapy combined with gemzar for treatment of unresectable pancreatic cancer.Methods: Gemzar at dose of 1000mg/m 2,28 days per cycle,drug was given at 1,8,15 days,for two cycles.After 24 hours all patients were treated with stereotactic radiotherapy.Per fraction was 5~7G Y,three times per week.The total dose was 40~48G Y.Results: 13 patients were followed up for one year,symptoms were reduced and median survival was 12 months.Conclusion: Stereotactic radiotherapy combined with gemzar has important valves for unresectabal pancreatic cancer.

  • 【文献出处】 中国现代普通外科进展 ,Chinese Journal of Current Advances in General Surgery , 编辑部邮箱 ,2003年04期
  • 【分类号】R735.9
  • 【被引频次】1
  • 【下载频次】35
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