【摘要】 目的 :观察异丙酚对家兔EEGδ频段的影响。方法 :应用定量药物EEG(QPEEG)功率谱分析法 ,分析静注异丙酚前后家兔脑电活动的变化。结果 :异丙酚 2 .5mg/kg对δ频段的功率百分比无明显影响 :5mg/kg使δ频段的功率百分比增大一倍以上 ,但未达显著性水平 (P >0 .0 5 ) ;10mg/kg使各脑区使δ频段功率百分比在 2 0s至 5min内均显著增大 (P <0 .0 1,P <<0 .0 5 ) ,且与行为变化平行 ,δ频段的改变与异丙酚剂量在 5min内均呈显著相关 (r=0 6 2～ 0 95 ,P <0 0 1)。结论 :异丙酚以剂量依赖方式增大家兔EEGδ频段的功率百分比 ,提示δ频段可能成为监测麻醉深度的指标更多还原

【Abstract】 Objective: To observe the effects of propofol on δ-band of EEG in rabbits.Methods:The changes of brain electrical activity was analyzed by means of spectral analysis of QPEEG in rabbits before and after intravenous injection of propofol.Results:The percentage of δ-band power showed no significant changes at the dose of 2 5mg/kg,but it increased more than one time,however it did not reached the significant level ( P >0.05) at the dose of 5mg/kg.When the dose of propofol reached 10 mg/kg the percentage of δ-band increased significantly in all brain regions,and moreover it was parallelism with the behavior alteration of the rabbit from 20s to 5min,A positive correlation was noted between δ-band power and propofol dose in 5min ( r=0 62-0 95,P <0.01),Conclusions:Propofol might increase the percentage of EEG δ-band by means of dose-dependance.It might suggest that the percentage of δ-band be a index of monitoring the anesthesia depth.更多还原