【摘要】 目的　观察参附注射液对重型脑外伤的临床疗效 ,探讨参附注射液对颅脑损伤的脑保护作用。方法　选择GCS5 - 8分患者 60例 ,根据同等伤情分为 2组 ,对照组 (Control) ,即单纯用一般的治疗方法 ;参附注射液治疗组 ,即在应用一般治疗同时 ,在患者入院后 2 4小时内通过静脉注射参附注射液 ,观察患者的临床症状体征、清醒时间、GCS评分、GOS预后评分、TCD血流速度改变和病死率等指标。结果　治疗组的症状体征较对照组改善明显 ,有效率明显高于对照组 (P <0 0 1) :清醒时间较对照缩短 (P <0 0 5 ) ,TCD显示MCA血流速度降低较多 (P <0 0 1) ;GCS评分和GOS预后积分均较对照组升高 (P <0 0 5或 0 0 1) ;病死率明显下降 ,对照组 40 % ,治疗组 2 0 %。结论参附注射液对重型颅脑损伤具有明显的脑保护作用 ,其疗效可靠 ,毒副作用较小 ,对治疗颅脑损伤具有一定的应用前景更多还原

【Abstract】 Objcctives:To investigate clinical effects and neuroprofective effects of shenfu in treatment of severe braniocerebral trauma.Method:60 patients(GCS5-8) were assigned into two groups, Shenfu group and control group with 30 cases in each group. Control group patients had been treated on routine and shenfu group had been treated with shenfu solution.The clinical features, consciousness, hemorrheology and Glasgow coma scale of the two groups were compared.Results: 1.The clinical features in treatment group were improved better than that in control.2.the time of awakening and conscious recovery in shenfu group were shorter than that in control. 3.In treatment group, TCD spectral form and blood flow speed approach normal, blood flow speed of control growp was faster. 4.Glasgow coma scale and Glasgow outcome scale increased than control group, fatality rate in treatment group was litter than that in treatment group.Conclusion:Shenfu slution posses neuroprotective effects, moreover, no side effects and complication was aslo found.更多还原