【摘要】 目的:探讨前列腺素E₁对家兔颈总动脉球囊损伤后再狭窄的防治作用。方法:20只家兔颈动脉球囊损伤术后,随机分成对照组（n=10）和前列腺素E₁组（n=10）,前列腺素E₁组术后每日静脉注射前列腺素E₁0.2μg/kg,共10天。各兔于术前、术后3天及1、2、4、8周留取静脉血,用放射免疫法检测血浆中血栓素A₂（TXA₂）代谢产物血栓素B₂（TXB₂）和前列环素（PGI₂）代谢产物6-酮-前列腺素F_1α(6-keto-PGF_1α);术后4、8周每组随机处死家兔各5只,留取颈总动脉行病理形态学观察。结果:术后3天及1、2周与对照组相比,前列腺素E₁组TXB₂明显降低,6-keto-PGF_1α明显升高,TXB₂/6-keto-PGF_1α明显降低（P<0.01）,术后4、8周逐渐恢复正常。术后4、8周,前列腺素E₁组动脉内膜、中膜厚度明显小于对照组（P<0.01）。结论:前列腺素E₁有抑制家兔颈动脉球囊损伤后内膜、中膜增厚和降低再狭窄发生率的作用。更多还原

【Abstract】 Objective: To investigate the preventive role of prostaglandin (PGE1)on restenosis after balloon-induced injury to carotid artery in rabbits. Methods: Balloon-induced injury in right common carotid artery was performed on twenty rabbits. After operation, all rabbits were randomly divided into control group ( n = 10) and PGE1 treated group ( n = 10). In PGE1-treated group, the rabbits were injected with PGE1 10 d(0. 2 μg· kg-1·d-1) through ear vein. Changes of the levels of plasma thromboxane B2, 6-keto-PGF1α and the ratio of TXB2/6-keto-PGF1α were measured by Radioimmunoassay (RIA) before operation and 3 days, 1, 2, 4, 8 weeks after operation respectively. Four weeks and eight weeks after injury, pathomorphological examination was performed. Results: ① Three days, 1, 2 weeks after injury, the levels of plasma thromboxane B2 were significantly decreased, the levels of plasma 6-keto-PGF1α were increased and the ratios of TXB2/6-keto-PGF1α were decreased markedly as compared with those of control group respectively ( P < 0. 01 ). ② Four weeks and eight weeks after injury, the intimal thickness and the medial thickness of right common carotid artery in PGE1-treated group were significantly thinner than those of control group ( P < 0. 01). Conclusion: PGE1 can effectively inhibit intima and media proliferation of artery in the rabbits after injury. Thus, PGE1 might have potentially clinical prospect in prevention and treatment of restenosis.更多还原