【摘要】 目的:研究神经内分泌标记嗜铬粒蛋白(CG)、突触素(Syn)和神经特异性烯醇化酶(NSE)在无功能胰岛细胞瘤中的表达及意义。方法:用链菌素亲生物蛋白-过氧化物酶法(S-P法)对我院收治的1988～2001年间共14例无功能胰岛细胞瘤石蜡标本进行了嗜铬粒蛋白(CG)、突触素(Syn)和神经特异性烯醇化酶(NSE)免疫组织化学研究。结果:14例无功能胰岛细胞瘤中NSE、CG和Syn的阳性表达分别有12、8和12例,阳性率分别为85.7％、51.7％和85.7％。除1例外,其余病例中3种激素至少有一种阳性表达。结论:CG、Syn、NSE在无功能胰岛细胞瘤中呈强阳性表达,是胰腺无功能胰岛细胞瘤的良好标记,联合检测有助于提高检测的敏感性。更多还原

【Abstract】 Objective: To study the expression of chromogranin, synaptophysin and neuron-specific enolase in nonfunctioning islet cell tumors. Methods: Fourteen paraffin-embedded specimens with nonfunctioning islet tumors were recruited from Jan 1988 to Jun 2001. The S-P method was used for the detection of chromogranin, synaptophysin and neuron-specific enolase. Results: There were positive expression of chromogranin, synaptophysin and neuron-specific enolase in 12, 8 and 12 cases saperatively. Conclusion: Non-functioning islet cell tumor can synthesize and secrete more than one hormone; CG,Syn and NSE may be ideal markers, those markers were altogether detected to promote the sensitivity.更多还原