Objective To observe dynamical changes of injured airway by way of establishing rat models of chronic obstructive pulmonary disease (COPD).Methods The rats were intratracheally instilled with lipopolysaccha- ride(LPS) twice and exposed to cigarette smoke to make COPD models,whose morphological changes of airways and lung tissue were dynamically observed; interleukin-8(IL-8) in the serum and bronchoalveolar lavage fluid (BALF) were detected. Results After the model are established,the epithelial cilia coh...
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