【摘要】 目的 :研究深圳地区健康人、HIV无症状感染者及AIDS患者的免疫状态 ,以了解艾滋病早期T细胞亚群的变化过程。方法 :应用流式细胞仪三色荧光单克隆抗体 (CD4-FITC/CD8-PE/CD3 -PC5 )检测 3 4例正常健康成人 ,1 2例HIV感染无症状者 ,2 3例AIDS患者的外周血CD+ 4 、CD+ 8T淋巴细胞计数及CD+ 4 /CD+ 8比值。结果 :HIV感染无症状者及AIDS患者的CD+ 4 淋巴细胞及CD+ 4 /CD8比值均明显低于健康成人 (P <0 0 1 ) ;HIV感染无症状者CD+ 8T淋巴细胞明显高于正常健康人和AIDS患者 (P <0 0 1 ) ;CD+ 4 T淋巴细胞随病程进展不断下降 ,AIDS患者与HIV感染无症状者之间存在着显著差异。结论 :T淋巴细胞免疫状况可作为评价AIDS病程进展程度的重要指标。更多还原

【Abstract】 Objective:To study the immunological status of HIV/AIDS patients and normal adults in Shenzhen and the changing process of T cell subsets in early clinic stage of AIDS. Methods:T cell subsets from 34 normal adults, 12 asymptomatic HIV carriers, 20 AIDS patients were detected by flow cytometer. Results:CD + 4 cell conuts and CD + 4/CD + 8 ratios of HIV/AIDS patients were much less than normal adults ( P<0.01 ), thile an evident increasing of CD + 8 cell count has been found in asymptomatic HIV carriers. The remarkable difference( P<0.01 ) of CD + 4 cell count between AIDS patients and asymptomatic HIV carriers was indicated in the investigation. Conclusion:The immunolgical status of T cell might be considered as an important indicator in AIDS stage.更多还原