【摘要】 目的 :探讨电针对慢性应激致空间学习记忆障碍大鼠海马胆碱能功能的影响。方法 :采用电击足底结合噪声应激建立大鼠学习记忆障碍模型 ,Morris水迷宫观察动物的空间学习记忆能力 ,放免法检测乙酰胆碱 (Ach)含量、胆碱乙酰转移酶 (ChAT)和乙酰胆碱酯酶 (AchE)活性。结果 :慢性应激可引起大鼠空间学习记忆功能障碍 ,海马Ach含量减少 ,ChAT和AchE活性降低。电针对上述改变有显著的保护作用。结论 :电针改善慢性应激引起的大鼠空间学习记忆功能障碍可能与其增强海马胆碱能系统的功能有关。更多还原

【Abstract】 Objective :To study the effect of electroacupuncture on the spatial learning and memory dysfunction induced by chronic stress and cholinergic function of hippocampus in rats. Methods :The learning and memory impairment model in adult rats was induced by electric foot companied with noise.The spatial learning and memory abilities were observed by Morris water maze.Radioimmunoassay technology was used to measured the content of acetylcholine(Ach) and the activity of choline acetyltransferase(ChAT) and acetylcholinesterase(AchE). Results :Chronic stress induced spatial learning and memory dysfunction,and the content of Ach and the activity of ChAT and AchE in hippocampus were significantly decreased.Electroacupuncture improved stressful rats cognitive function and increased the content of Ach and the activity of ChAT and AchE in hippocampus. Conclusions :Improvement of the spatial learning and memory dysfunction by electroacupuncture in rats induced by chronic stress maybe via cholinergic nervous systerm in hippocampus.更多还原