【摘要】 用尿素和氨基乙醇为原料 ,以DMF为反应溶剂合成了 2 -口恶唑烷酮。产品结构经红外和核磁共振氢谱确认。研究了主要反应条件对合成收率的影响 ,确定了最佳反应条件为 :尿素、氨基乙醇和DMF的物质的量之比为 1∶1∶3.4 2 ,反应温度为 170℃ ,反应时间为 6h。在此条件下 ,产品 2 -口恶唑烷酮的收率可达 85 %以上。反应溶剂DMF可回收利用 ,产品收率不下降。简化了后处理过程 ,只需少量无水乙醇洗涤产品即可 ,节约了成本 ,适宜工业化生产更多还原

【Abstract】 Oxazolidinone was prepared by using urea and amino-ethanol as raw materials,and DMF was used as reaction solvent.The structure of product was confirmed by IR and HNMR.The effects of the main reaction conditions on synthetive yield were researched and the optimal conditions were as follows: the amount-of-substance ratio of urea,amino-ethanol and DMF was 1∶1∶3.42;reaction temperature was 170 ℃;reaction time was 6 h. under this conditions, the yield of product 2-oxazolidinone could reach above 85 %. The reaction solvent DMF could be reclaimed and the yield of product was not lower.The process of after-treatment was simplied and a little absolute ethanol was only needed to wash the product,which saved the costs.更多还原