【摘要】 以西咪替丁为印迹分子,2-丙烯酰胺-2-甲基丙磺酸 (AMPS) 为功能单体,三羟甲基丙烷三甲基丙烯酸甲酯 (TRIM) 为交联剂,采用乳液聚合法制备了亚微米级分子印迹聚合物微球。利用扫描电镜对此聚合物微球的形貌进行了观察,探讨了影响乳液稳定性、粒径大小与分布的主要因素,重点对聚合工艺和配方进行了优化,并将所得的聚合物用作吸附剂研究了其分子识别与选择性能。研究表明,乳液聚合法能够制得单分散性较好的、平均粒径在0.169m~0.407m的分子印迹聚合物微球,且该微球对其印迹分子呈现出较好的特异识别与选择性能,当以苯丙氨酸为竞争分子时,分离因子可达1.70。更多还原

【Abstract】 In this paper, a novel method of emulsion polymerization was introduced to prepare the imprinted polymeric microspheres in submicrometer size in water system using cimetidine as printing molecule, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as functional monomer and trimethylolpropane trimethacrylate (TRIM) as cross-linker. The appearance of the beads were observed by scanning electric microscope (SEM), the stability of emulsion; the sizes and size distribution were studied and the major factors that influence these properties were discussed as well, based on which the polymerizing techniques was optimized. At last, the molecule recognition and selecting properties of the microspheres were evaluated. The results showed that monodisperse imprinted microspheres were obtained by emulsion polymerization and the average size was between 0.169祄 and 0.407祄. The cimetidine imprinted microspheres exhibited a considerable capability of molecule recognition and selectivity to its printing molecule. The separate factor was 1.70 when phenylalanine was used as competitive molecule.更多还原