【摘要】 目的 探讨血管细胞粘附分子 -1(VCAM -1)与2型糖尿病大血管病变的关系。方法 用ELISA法测定了18例有大血管病变和20例无大血管病变的2型糖尿病患者的血清可溶性血管细胞粘附分子 -1(sVCAM -1)水平。两组的年龄、性别构成及空腹血糖水平均无显著性差异。结果 与无糖尿病大血管病变组患者相比 ,有糖尿病大血管病变组患者的sVCAM -1水平明显增高[(644.28±75.97)ng/MLvs(424.85±82.79)ng/ML,p<0.01]。结论 VCAM -1可能参与了糖尿病大血管病变的发生 ,测定sVCAM -1会有助于糖尿病大血管病变的早期诊治更多还原

【Abstract】 To study the relationship between soluble vascular cell adhesion molecule-1(VCAM-1)and macrovascular complication of type 2 diabetic patients. Methods 38 patients with type 2 diabetic were employed in our study, who had no hypertension and hyperlipemia. All patients were divided into two groups matched for age, sexand fasting blood glucose level. One was macrovascular complication group(n=18 ,who had macrocascular complications in lower leg),the other was control group(n=20, who had no macrocascular complications).Serum sVCAM-1 level was measured in all patients by enzyme-linked immunosorbent assay. Result The serum sVCAM-1 level of macrovascular complication group is significantly higher than that of control group (644.28±75.97ng/ml vs 424.85±82.79ng/ml,t=8.48, p<0.01). Conclusion sVCAM-1 May play a role in the pathogenesis of diabetic macrovascular complication in type 2 diabetes mellitus. The determination of serum sVCAM-1 may be useful for early diagnose and treatment of diabetic macrovascular complication.更多还原