【摘要】 目的 :了解Graves病合并肝功能异常的发生率、临床表现及相关因素。方法 :1990～ 2 0 0 1年复旦大学附属华山医院收治Graves病住院患者 312例 ,分析其临床表现 ,肝功能指标 ,血清甲状腺激素水平以及甲状腺自身抗体水平。结果 :312例患者中 ,Graves病合并肝功能异常的发生率为 5 0 .3%。这些患者的甲状腺激素水平、TsAb水平显著高于无肝功能异常患者 ;同时 ,他们合并甲亢性心脏病的比例更高。抗甲状腺药物治疗后 ,肝功能的恢复与甲状腺激素水平的回落一致。结论 :Graves病合并肝功能异常的发生率较高 ,与患者的甲状腺激素水平、TsAb水平关系密切更多还原

【Abstract】 Objective: To investigate the prevalence,the clinical characteristics and the possible risk factors of hepatic dystunction in patients with Graves’ disease(GD). Methods: Clinical records of 312 patients with hyperthyroidism (caused by GD) from 1990～2001 were studied. In all patients ,the liver fuction tests, serum thyroid hormone and TsAb were reexamined. Results: in 157(50.3%,95% CI) of the 312 patients At least one liver fuction test was changed. In the patients with hepatic dystunction, the serum thyroid hormone levels and TsAb were significantly higher, also, they were more often complicated with heart diseases. Along with the normalized thyroid hormone levels, ALT levels returned to normal in most patients. Conclusion: Hepatic dystunction in GD patients is common, and there was correlation between the elevation of ALT levels and the thyroid hormone and TsAb levels.更多还原