【摘要】 目的 :研究辛伐他汀对原发性高血压 (EH)并高胆固醇血症患者血管内皮依赖性舒张功能的影响。方法 :采用高分辨超声技术 ,对 2 4例EH并高胆固醇血症患者 (A组 )降脂前后和 2 0例血浆胆固醇水平正常的对照者 (B组 )血管内皮依赖性舒张功能进行检测。结果 :A组患者服用辛伐他汀 10mg治疗 8周后肱动脉血流介导性舒张较B组明显减弱 [(2 .99± 2 .2 4 ) %∶(7.0 1± 2 .73) % ,P <0 .0 1],且对硝酸甘油的反应差异亦有显著性意义[(8.2 8± 5 .12 ) %∶(12 .2 8± 4 .84 ) % ,P <0 .0 5 ]。血浆总胆固醇从 (6 .39± 0 .71)mmol L降至 (5 .2 3± 0 .33)mmol L ,同时肱动脉内皮依赖性舒张较治疗前明显改善 [(7.82± 1.2 9) %∶(2 .99± 2 .2 4 ) % ,P <0 .0 1],而治疗前后肱动脉对硝酸甘油的反应无显著性改变。结论 :EH并高胆固醇血症患者存在血管内皮依赖性舒张功能障碍 ;经辛伐他汀降胆固醇治疗后 ,受损的血管内皮依赖性舒张功能得到明显改善更多还原

【Abstract】 Objective:To investigate the effect of simvastatin on endothelium dependent dilational function in the hypertensive patients with hypercholesterolemia.Methods:With high resolution ultrasound, we study endothelium dependent dilational function in 44 subjects: 20 with normal blood cholesterol and 24 primary hypertensive patients with hypercholesterolemia.Results:In the hypertensive patients with hypercholesterolemia, flow mediated dilatation in arteries was more reduced compared with control group ( 2.99 ± 2.24 )% vs ( 7.01 ± 2.73 )%, P< 0.01 , and there was significant difference in reaction to nitroglycerin between these groups ( 8.28 ± 5.12 )% vs ( 12.28 ± 4.84 )%, P< 0.05 . Twenty four patients with hypertension and hypercholesterolemic were received cholesterol lowing therapy with simvastatin for 8 week, by which serum cholesterol reduced ( 6.39 ± 0.71 ) mmol/L to ( 5.23 ± 0.33 ) mmol/L (P< 0.01 ). Flow mediated vasodilations improved significantly after simvastatin therapy ( 7.82 ± 1.29 )% vs ( 2.99 ± 2.24 )%, P< 0.001 ). The vasodilation response to nitroglycerin had no significant change after cholesterol lowing therapy.Conclusion:Endothelium dependent vasodilation was impaired in the hypertensive patients with hypercholesterolemia, and cholesterol lowing therapy with simvastatin may improve impaired endothelium dependent vasodilation.更多还原