【摘要】 目的 :探讨索他洛尔对急性心肌梗死 (AMI)血小板活化、纤溶活性和内皮血管活性物质的影响。方法 :新西兰大白兔 4 0只 ,随机分为 4组 ,每组 10只 ,Ⅰ组 :假手术组 ,Ⅱ组 :AMI组 ,Ⅲ组 :利多卡因组 ,Ⅳ组 :索他洛尔组 ;Ⅱ、Ⅲ、Ⅳ组分别结扎冠状动脉左室支中点 ,4h后取血分别测定血栓素B2 (TxB2 )、6 酮 前列腺素F1α(6 keto PGF1α)、内皮素 (ET)、一氧化氮 (NO)浓度和组织型纤溶酶原激活剂 (t PA)、纤溶酶原激活剂抑制物 (PAI)活性 ;摘取心脏 ,测定心肌梗死范围。结果 :Ⅱ、Ⅲ、Ⅳ组与Ⅰ组比较 ,血浆TxB2 、ET、NO浓度和PAI活性显著升高(P <0 .0 1) ,6 keto PGF1α浓度、t PA活性显著下降 (P <0 .0 1) ,Ⅲ组与Ⅱ组比较 ,差异无显著性意义 ,Ⅳ组与Ⅱ组比较 ,血浆TxB2 、ET、NO浓度和PAI活性明显降低 (P <0 .0 1) ,6 keto PGF1α浓度、t PA活性显著升高 (P <0 .0 1) ,梗死范围减小。结论 :索他洛尔抑制AMI早期血小板活化 ,改善纤溶活性 ,减少ET和NO的释放 ,缩小心肌梗死范围更多还原

【Abstract】 Objective:To study the effects of sotalol on platelet activation, fibrinolytic activity and the vasoactive mediators in rabbit acute myocardial infarction (AMI) model. Methods:Fourty new Zealand white rabbits were randomly assigned to four groups. Group Ⅰ: sham group, Group Ⅱ: AMI group, Group Ⅲ: lidocaine group, Group Ⅳ: sotalol group.The middle point of left ventricular coronary artery was ligated (GroupⅡ, Ⅲ and Ⅳ ) or a sham ligation(Group Ⅰ), four hours later, blood was collected for measuring plasma concentration of TxB 2, 6 keto PGF 1α , ET and NO and plasma activity of t PA and PAI. After that, the heart was taken out to evaluate the infarct size (IS). Results:Plasma levels of TxB 2, ET and NO and plasma activity of PAI were significantly higher in Group Ⅱ, Ⅲ and Ⅳ than those in Group Ⅰ(P< 0.01 ), but the plasma concentration of 6 keto PGF 1 and plasma activity of t PA were remarkably decreased in Group Ⅱ, Ⅲ and Ⅳ than those in Group Ⅰ(P< 0.01 ), There were no difference between Group Ⅱ and Group Ⅲ. In Group Ⅲ plasma concentration of TxB 2, ET and NO and plasma activity of PAI were significantly decrease (P< 0.01 ), the plasma concentration of 6 keto PGF 1α and plasma activity of t PA were remarkably increase(P< 0.01 ), the infarct size were significantly decrease(P< 0.01 )compared with Group Ⅰ. Conclusion:Sotalol can inhibit platelet activation, improve fibrinolytic activity and decrease release of ET and NO in AMI model.更多还原