【摘要】 目的 :研究不稳定型心绞痛 (UAP)患者血中免疫反应标记物新蝶呤和炎症反应标记物白细胞介素 6 (IL 6 )的变化。方法 :采用酶联免疫法测定 77例经冠状动脉造影证实的冠心病患者血中新蝶呤、IL 6、C 反应蛋白 (CRP)的浓度。 77例中UAP 36例 ,年龄 4 2～ 82 (6 3± 11)岁 ;慢性稳定型心绞痛 (SAP)患者 4 1例 ,年龄 4 0～ 80(6 4± 9)岁。结果 :与SAP患者相比 ,IL 6〔(12 .72± 13.4 2 )∶(7.0 1± 3.0 8)ng/L ,P <0 .0 1〕、CRP〔(2 .0 3± 3.6 8)∶(0 .85± 0 .99)mg/L ,P <0 .0 5〕、新蝶呤〔(7.0± 3.16 )∶(5 .38± 3.2 0 )nmol/L ,P <0 .0 5〕及经血肌酐校正的新蝶呤水平 (× 10 -2 ) (7.5 9± 2 .87∶5 .0 9± 2 .86 ,P <0 .0 1)在UAP患者中显著增高。结论 :新蝶呤和IL 6、CRP在UAP患者中增高 ,均可作为提示斑块不稳定性的指标 ,辅助UAP的诊断。免疫反应和炎症反应均参与了UAP的发生更多还原

【Abstract】 Objective:To investigate the change of the immune marker neopterin and the inflammatory marker IL 6 in patients with unstable angina.Methods:In 77 patients with coronary artery disease diagnosed by angiography, there were 36 cases with unstable angina, age(63±11)years, and 41 patients with chronic stable angina, age(64±9)years. ELISA was used to measure neopterin, IL 6 and C reactive protein (CRP).Results:IL 6, CRP and neopterin corrected by serum creatinine were significantly elevated in unstable angina group than those in chronic stable angina group.Conclusion:Neopterin, IL 6 and CRP are elevated in unstable angina patients, they can be used as markers of vulnerable plaque and support the diagnosis of unstable angina. This study also supports the hypothesis that both immune and inflammation have roles in unstable angina.更多还原