【摘要】 目的 比较帕罗西汀与阿普唑仑治疗广泛性焦虑症的疗效与副反应。方法对符合CCMD-3广泛性焦虑症诊断标准的病人。随机分为帕罗西汀组和阿普唑仑组,治疗6w,用汉密尔顿焦虑量表(HAMA)、Zung焦虑自评量表(SAS)、临床疗效4级评分标准和药物不良反应症状量表(TESS)评定疗效和药物副反应。结果帕罗西汀的疗效与阿普唑仑相当,未见有严重副反应和成瘾性,但起效稍慢于阿普唑仑。结论帕罗西汀治疗广泛性焦虑症疗效确切,不良反应轻,服药方便,治疗依从性好。更多还原

【Abstract】 Objective To compare the curative effects and side effects of paroxetine and alprazolam in patients with generalized anxiety disorder. Methods Sixty - three patients met CCMD - 3 criteria for generalized anxiety disorder were divided into paroxetine group (n = 31) and alprazolam group (n = 32) for 6 weeks of treatment. Curative effects and side effects were evaluated with HAMA, SAS and TESS and so on. Results Paroxetine had similar curative effect to alprazolam, but it took effect slowly and had no serious side effects and addiction. Conclusion Paroxetine has better curative effect and compliance, mild side effects in treatment of patients with generalized anxiety disorder.更多还原