【摘要】 目的　测定冠心病患者血浆神经肽Y(NPY)的浓度 ,分析其与血糖、血脂、血胰岛素以及其他因素的关系。方法　选择冠心病患者 5 1例 (冠心病组 ) ,将其分为血脂异常组 2 8例 ,血脂正常组 2 3例。选择年龄相配的健康者 2 7名 (对照组 )进行对照。分别测定身高、体重及血浆NPY、血糖 (FBG)、血胰岛素 (FIN)、血脂 (TC、TG、LDL C)、计算体重指数 (BMI)及胰岛素敏感指数 (ISI)。结果　 ( 1)冠心病组患者体重指数及血浆NPY明显高于对照组 (P <0 .0 5～P <0 .0 1) ,ISI与对照组比较显著下降 (P <0 .0 1) ,且NPY在冠心病组患者中与BMI、FIN、TG和ISI有明显相关性。 ( 2 )冠心病组血脂异常组血浆NPY水平明显高于血脂正常组 ,两组NPY水平均明显高于对照组。结论　NPY在动脉粥样硬化和冠心病的发生中起一定作用更多还原

【Abstract】 Objective To observe the relation of plasma neuropeptide y(NPY)with blood glucose,lipide and insulin in CAD patients.Methods Weight,height and fasting plasma TC,TG,LDL C,NPY,glucose(FBG),insulin(FIN)were measured in 27controls and 51 CAD patients.Insulin sensitivity index(ISI)and body weight index(BMI)were calculated.Among the 51 CAD patients, there were 28 patients with dyslipidemia and 23 patients with eulipidemia.Results The plasma NPY,FIN levels and BMI were significantly higher and ISI was significantly lower than that of in the control.Plasma NPY concentrations were found to be significantly associated with BMI,FIN,TG and BMI in CAD patients.The plasma NPY level in CAD patients with eulipidemia were significantly higher than that of in the control,but significantly lower than that of CAD patients with dyslipidemia.Conclusions NPY may play an important role in the pathogenesis of atherosclerosis and coronary artery disease.更多还原