【摘要】 目的　了解血清透明质酸 (HA)、层粘蛋白 (LN)和Ⅳ型胶原 (CⅣ )与肝脏炎症活动度及纤维化程度的关系。方法　对比分析慢性乙型肝炎患者血清HA、LN、CⅣ水平与肝脏病理诊断。结果　血清HA、LN、CⅣ由G0 G4、S0 S4依次升高 ,但在各级及各期间升幅不全一致 ,以HA上升最早 ,级间升幅较大 ,LN在S2期后开始大幅升高 ,而CⅣ于S2期前即有大幅升高 ;血清HA、LN、CⅣ水平与肝病分级及分期均呈正相关。结论　HA对慢性肝炎病情严重程度判断价值较大 ,HA和CⅣ似有诊断早期肝纤维化的价值 ,LN可协助诊断中晚期肝纤维化。肝脏炎症活动度与纤维化程度有重叠现象 ,单一血清指标的特异性较差更多还原

【Abstract】 Objective To investigate the relationship of s erum hyaluronic acid(HA),laminin(LN),type Ⅳ collagen(CⅣ)and liver inflammati on and fibrosis.Methods Liver biopsy was performed in 130 patients with chronic hepatitis B for histology examination.Serum HA,LN,CⅣ were tested by EIA.Results Serum HA,LN and CⅣ increased with inflammatory grades from G0 to G4 and the fibrosis stages from S0 to S4,respectively.HA increased first and with a higher degree than LN and CⅣ did.LN increased form the stage S2,and CⅣ increased as earlyas S1.Serum HA,LN and CⅣ were positive correlate d with the degrees of liver inflammation and stages of liver fibrosis.Conclusion Serum HA,LN and CⅣ increased with the advancement of hepatic inflammation and liver fibrosis,HA is valuable to assess the severi ty of chronic hepatitis.HA,CⅣ and LN are useful in diagnosing and staging of c irrhosis,but each single marker was less special.It is necessary to combine ser um HA,LN,CⅣ and clinical data for diagnosis of chronic hepatitis.更多还原