【摘要】 目的　分析支气管肺泡灌洗液 (BALF)及纤支镜防污染毛刷 (PSB)标本中检出的甲型溶血性链球菌的菌种分布 ,初步探讨其临床致病性。方法　从肺泡灌洗液及纤支镜刷标本中分离出甲型溶血性链球菌 ,用微生物鉴定系统鉴定到种 ,统计菌种分布与患者临床疾病的关系。结果　 2 6 9例BALF及PSB标本中共检测到甲型溶血性链球菌 5 1株 (19.0 % ) ,其中缓症链球菌群 31株 ,占 6 0 .8% ,咽峡炎链球菌群 10株 (19.6 % ) ,变异链球菌 2株 (3.9% ) ,唾液链球菌 3株 (5 .9% ) ,血液链球菌 2株(3.9% )和乳房链球菌 3株 (5 .9% )。检出甲型溶血性链球菌患者的基础疾病依次为肺炎 31.4 % (16 /5 1) ,慢性支气管炎急性发作 19.6 % (10 /5 1)、肺结核伴感染 17.6 % (9/5 1)、支气管扩张伴感染 11.8% (6 /5 1)、肺癌 7.8% (4/5 1)、肺囊肿 5 .9% (3/5 1)、肺叶切除术后 3.9% (2 /5 1)及创伤性气胸 2 .0 % (1/5 1)。结论　BALF及PSB标本中检出甲型溶血性链球菌与感染患者临床症状有关。在有感染体征和免疫力低下的患者 ,应加做血培养以排除此类细菌引起的菌血症及败血症更多还原

【Abstract】 Objective To analyze the distribution of Streptococcus viridans species isolated from the specimens of bronchoalveolar lavage fluid and thebrush of fibrobronchoscope,and discover their clinical pathogenicity.Method Streptococcus viridans was isolated from specimens of bronchoalveolar lavage fluid and the brush of fibrobronchoscope.The species were identified by Microbial Identification System.The distribution of species was analyzed by statistical approach and the clinical pathogenicity was evaluated by the clinical data of corresponding patients.Result Among all the 269 specimens, a total of 51 Streptococcus viridans were found including 31(61.8%) of Strep.mitis,10(19.6%) of Strep.anginosus,2(3.9%) of Strep.mutans,3(5.9%) of Strep.salivarius,3(5.9%) of Strep.sanguis and 3 (5.9%) of Strep.Uberis.Conclusion The species of Streptococcus viridans from bronchoalveolar lavage fluid and brush of fibrobronchoscope were correlated with the clinical symptoms of patients.For the patients with infectious signs or immunodeficiency blood culture must be important to find the occurrence of bacteremia or septicaemia caused by Streptococcus viridans.更多还原