【摘要】 研究了银杏叶聚戊烯醇(GP)联合化疗S180肿瘤的药效作用。从银杏叶中分离纯化聚戊烯醇,分别与阿霉素注射液(ADM)、氟脲嘧啶(5 Fu)、环磷酰胺(CTX)和顺铂(PDD)等化疗药联合用药,对S180荷瘤小鼠进行抑瘤实验,并与ADM、5 Fu、CTX和PDD单独用药比较。研究表明,聚戊烯醇与CTX、PDD、5 Fu联合化疗,对S180的抑瘤率分别从59.81%、43.06%、42.03%提高到70.56%、60.29%、63.45%;与ADM联合化疗,可使1.0mg/kg的ADM对S180的抑瘤率从50.93%提高到77.19%。研究结果表明,银杏叶聚戊烯醇具有明显的辅助化疗和减毒增效作用。更多还原

【Abstract】 Pharmacology of polyprenols from Ginkgo biloba L.leaves(GP) in combination with chemotherapeutic drugs on tumor was studied.Polyprenols separated and purified from G.biloba L.leaves were administered in combination with adriamycin(ADM),5flauouracil(5Fu),cyclophosphamide(CTX) and cisplatin(PDD) respectively,in contrasting with ADM,5Fu,CTX and PDD alone.Experiments were carried out on mouse with transplanted S180.Results show that for polyprenols in combination with CTX,PDD and 5Fu,the inhibition of S180 nodule was raised from 59.81%,43.06% and 42.03% to 70.56%,60.29% and 63.45% respectively,in contrasting with their administration alone.For ADM in combination with polyprenols,1.0 mg/kg ADM had raised the inhibition of S180 nodule from 50.93% to 77.19%.Results showed that polyprenols have a significant subsidiary effect on chemotherapy,along with reduced toxicity.更多还原