【摘要】 探讨慢性乙型病毒性肝炎简称(慢乙肝)谷丙转氨酶(ALT)反复波动与干扰素(IFN)干扰素抗体(an-IFN),白介素Ⅱ(IL-2),肿瘤坏死因子(TNF)在血清中含量变化关系。方法:使用ELISA和RIA法检测50例慢乙肝患者为观察组和50例曾用过干扰素治疗的慢乙肝患者,50例健康人做2组对照。结果:三组中IFN、an-IFN血清含量无显著差异(P>0.05),IL-2血清含量干扰素治疗组明显高于观察组,健康人血清中IL-2水平也明显高于观察组(P<0.01),TNF在干扰素治疗组与观察组相比无显著差异(P>0.05)。故,此研究检测IL-2含量对判断慢乙肝患者发病机理及治疗有一定指导意义。更多还原

【Abstract】 To investigate the relation between ALT fluctuation of chronic virus hepatitis B and the concentration variation of IFN,an - IFN,IL- 2,TNF. Serums were obtained from three groups - the first group includes 50 chronic virus hepatitis B patients, the second group 50 chronic virus hepatitis B patients who have been treated with interferon, the third group includes 50 healthy individuals . The concentration of IFN,an - IFN,IL- 2,TNF were examined by ELISA and RIA. IFN,an - IFN levels have no significant difference among three groups. The concentration of IL- 2 in the second group and third group is significandy higher than in the first group; the concentration of TNF in the second group treated with interferon is higher than that in the first group and in the third group. The concentration of TNF in serum has no obvious difference between the first group and die third group. This showed that the testing of IL -Ⅱ has directive significance in paihogenesis and therapy of chronic virus hepatitis B.更多还原