【摘要】 目的　了解辛伐他汀对糖尿病血脂异常的调节作用。方法　比较 6 3例 2型糖尿病合并血脂异常采用胰岛素强化治疗 [即胰岛素泵持续皮下注射胰岛素 (CSII)或者多次 (>4次 /d)皮下注射胰岛素 (MSII) ]并连续服用辛伐他汀 2周与 4 2例 2型糖尿病合并血脂异常单纯采用胰岛素强化治疗 (CSII或者MSII) 2周后血脂的变化情况 ,同时了解治疗前后的空腹血糖 (FBS)、餐后 2小时血糖、肝功能 (LF)、肾功能 (SPS)及心肌酶学等的变化。结果　胰岛素强化治疗并连续服用辛伐他汀治疗组血脂显著变化 (P <0 .0 0 1 ) ,而单纯胰岛素强化治疗组血脂变化不明显 (P >0 .0 5 ) ,前者调节糖尿病合并血脂异常有效率达 93.6 % ,且副作用发生率低 (7.93% )而轻微。结论　辛伐他汀对 2型糖尿病合并血脂异常的调节作用疗效肯定 ,副反应小 ,可作为常用药物更多还原

【Abstract】 Objective To investigate the effect of simvastatin on diabetes mellitus incorporated with lipid abnormalities.Methods To compare two groups with the changes of lipid,one group was sixty three patients of type 2 diabetes incorporated with lipid abnormalities,adopted therapy with continuous subcutaneous insulin infusion(CSII) or multile subcutaneous insulin injection (MSII) and treated with simvastatin for two weeks,the other group was forty two patients of type 2 diabetes incorporated with lipid abnormalities,adopted therapy by only CSII or MSII. At the same time, the transformation of the fast blood sugar, the postprandial blood sugar after two hours, liver function and kidney function, cardiac muscle enzymology etc was compared. Results There was a remarkable change of lipid on the group added with CSII or MSII and treated with simvastatin for two weeks (P< 0.001 ), however there was a small change of lipid on the other group(P> 0.05 ). The effective rate of the former group was 93.6% ,while the side effect was low and light only 7.93 %. Conclusion The curative effect of simvastatin on the type 2 diabetes incorporated with lipid abnormalities was affirmative,and its side effect was very low,it is supposed to be as a common medicine to the type 2 diabetes incorporated with lipid abnormalities.更多还原