【摘要】 目的　探讨洛沙坦 (氯沙坦 )和苯那普利单用、联合治疗肾性高血压的临床效果。方法　对 30例单用洛沙坦 (A组 )和 2 7例单用苯那普利 (B组 )及 30例联合治疗患者 (C组 )比较 ,观察其治疗前后血压、2 4小时尿蛋白、血肌酐、肝功能、血脂的变化及不良反应。结果　 3组治疗后 2周血压较治疗前即有所下降 ,联合用药组 2～ 4周明显下降 (P <0 .0 5 ) ,单独用药的两组 4周后血压才明显下降 (P <0 .0 5 )。联合用药组血肌酐 (Cr)第 1 2周时有明显下降(P <0 .0 5 ) ,单独用药的两组Cr无明显下降 (P >0 .0 5 )。 3组治疗前后尿蛋白均有明显减少 (P <0 .0 5 ) ,单独用药的两组尿蛋白降低程度差异无统计学意义 (P >0 .0 5 ) ,联合用药组尿蛋白降低程度与单独用药的两组比较差异有统计学意义 (P <0 .0 5 )。 3组治疗前后肝功能、血脂无明显变化 ,洛沙坦组无明显不良反应。结论　洛沙坦和苯那普利联合治疗肾性高血压较单独使用更能有效控制血压 ,减少蛋白尿 ,降低血肌酐更多还原

【Abstract】 Objective To study the effects of Losartan and Benazepril on renal hypertension when they were both used or only one was used. Methods Blood pressure, 24 hours urine protein, blood creatinine, liver function, blood cholesterol, and side effects were compared among 30 patients with Losartan, 27 cases with Benazepril, and 30 cases with both of them before and after treatment. Results The blood pressure had been diminished in the three groups of patients after two weeks treatment, and more apparent in these cases with two drugs after two weeks (P< 0.05 ), and more apparent in the groups with only one drug after 4 weeks (P< 0.05 ). The blood creatinine diminished in the cases treated with both of them after 12 weeks (P< 0.05 ), and no difference in these cases showed with only one of them (P> 0.05 ). The urine protein decreased in three groups of cases (P< 0.05 ), without apparent difference (P> 0.05 ) in the groups with only one drug, but apparent difference (P< 0.05 ) in the groups with both of them. There are no changes in liver function, blood cholesterol before and after treatment. There are few side effects using Losartan. Conclusion Losartan and Benazepril both have better effects in decreasing blood pressure, urine protein and blood creatinine than only one of them in patients with renal hypertension.更多还原