【摘要】 目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者自主神经系统的功能状态及手术治疗效果。方法 :选择进行多导睡眠监测法监测的患者 77例 ,其中OSAS患者 6 1例 ,以AHI<5的 16例作为对照组。将 16例腭咽成形术患者进行手术前后比较。采用心率功率谱分析法 (HRPSA)对自主神经系统的功能进行定量分析。结果 :OSAS患者交感和迷走神经张力明显增高 ,且以交感神经的张力增高更为显著 ,并随病情的加重逐渐增高。手术治疗后交感和迷走神经张力明显降低 ,差异具有显著性意义。结论 :OSAS患者存在自主神经系统功能的异常活动 ,通过有效的手术治疗可缓解交感和迷走神经的异常张力 ,从而纠正心率和血压的异常变化更多还原

【Abstract】 Objective:To explore the nocturnal variation of autonomic nervous system (ANS) in patients with obstructive sleep apnea syndrome (OSAS) and the transformation after surgery.Method:Sixty one subjects with OSAS were recruited to undergo 7 hour nocturnal polysomnography(PSG)in sleep lab.Sixteen subjects with OSAS were performed PSG before and after UPPP.Sixteen subjects without OSAS were included as controls. Power spectrum analysis of heart rate variability (HRV) was performed in each subject.Result:The nocturnal of ANS activities were abnormal in patients with OSAS, especially the enhancement of sympathetic nervous activity. It increased gradually along with aggravating condition.The activities of sympathetic and vagus nerve were decreased significantly.Conclusion:There are abnormal ANS activities in patients with OSAS.Effective treatment of OSAS by surgery will significantly reduce the parameters of ANS, and redress the abnormality of heart rate and blood pressure.更多还原