【摘要】 目的 :比较局部和全身给药后 2 1 氢化琥珀酸 泼尼松龙在外淋巴液中的药物动力学。方法 :将实验豚鼠分组 ,局部用药 (局部组 ) :将 0 .5 %的 2 1 氢化琥珀酸 泼尼松龙液在直视下置于圆窗龛 ;全身用药 (全身组 ) :按 6 0mg/kg腹腔内注药 ;两组均以生理盐水作为对照。分别于给药后不同时间段采集外淋巴液标本 ,采用高压液相色谱法 (HPLC)测定药物浓度。结果 :局部组药物最高浓度出现在给药后 180min ,为 (95 2 .3± 382 .7)mg/L ,并在 96 0min后维持在 (18.72± 16 .97)mg/L。全身组药物最高峰时间在给药后 15 0min ,为 (14 .71± 7.0 5 )mg/L。结论 :局部给予 2 1 氢化琥珀酸 泼尼松龙 ,可以获得长时间、高浓度的药物水平。更多还原

【Abstract】 Objective:The present study was to analysis the pharmacokinetics of prednisolone 21 hydrogensuccinate in the perilymph after local and systemic application.Method:On the local application, 5% prednisolone 21 hydrogensuccinate was directly applied into the round window niche under the microscopy. On the systemic application, the drug (60 mg/kg) was used intraperitoneal. Perilymphatic samples were obtained after variable periods of application. Levels of prednisolone 21 hydrogensuccinate in perilymph were measured by using HPLC.Result:The highest level of the drug was on ( 952.3 ± 382.7 ) mg/L after 180 min. And remained on ( 18.72 ± 16.97 ) mg/L after 960 min in the local application groups.In the systemic application group, the highest level of the drug was on( 14.71 ± 7.05 ) mg/L after 150 min.Conclusion:The results demonstrate that high levels and long time remain of prednisolone 21 hydrogensuccinate in perilymph are achievable by a single dose local application into the round window niche.更多还原