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转化生长因子β₁与其Ⅱ型受体在喉癌中的表达及生物学意义

A study on the expression of TGF-β₁/TβRⅡin laryngeal carcinoma

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【Author】 YANG Shuzhi 1 LI Lingxiang 2 HAN Jun 2 CHEN Haiyan 2 ZHANG Wei 3 FAN Erzhong 3 LI Ying 3 ( 1Department of Otolaryngology, Inner Mongolia Hospital, Huhehaote 010070; 2Department of Otolaryngology, the First Affiliated Hospital, Inner Mongolia Medical College; 3Beijing Institute of Otolaryngology)

【机构】内蒙古医院耳鼻咽喉科；内蒙古医学院第一附属医院耳鼻咽喉科；北京市耳鼻咽喉科研究所；北京市耳鼻咽喉科研究所呼和浩特； 010070；

【摘要】目的 :探讨转化生长因子 β1(TGF β1)及其Ⅱ型受体 (TβRⅡ )在喉癌中的表达情况及其生物学意义。方法 :采用免疫组化SP法对 5 3例喉癌和 4 8例癌旁组织中TGF β1、TβRⅡ的表达情况进行检测。结果 :喉癌TGF β1的表达明显低于癌旁组织 (P <0 .0 5 )。TβRⅡ的表达与癌旁组织对照差异无显著性意义 (P >0 .0 5 ) ,但与肿瘤组织分化程度、临床分期和淋巴结转移密切相关。结论 :TGF β1和TβRⅡ参与调控喉癌的发生、发展和转移过程 ,TGF β1和TβRⅡ是监测喉癌的有用指标。更多还原

【Abstract】 Objective:To explore the expression of TGF β 1/TβRⅡin laryngeal carcinoma.Method:Immunohistochemical study using SP kit in 53 cases.Result:The expression of TGF β 1 was decreased in carcinoma tissues when compared with peri cancer controls (P< 0.05 ). There wasn’t difference in TβRⅡexpression when compared with peri cancer controls (P> 0.05 ). But it was correlated with the stage?differentiation and lymph node metastasis of laryngeal carcinoma.Conclusion:TGF β 1/TβRⅡ may involve in the histogenesis and development of laryngeal carcinoma. The decreased expression of TGF β 1/TβRⅡ may serve as an important molecular marker of laryngeal carcinoma.更多还原