【摘要】 目的 :考察降钙素基因相关肽 (CGRP)及其吸收促进剂二甲倍他环糊精 (MDβCD)对鼻粘膜纤毛的毒性。方法 :以生理盐水和盐酸麻黄碱作阴性对照 ,采用离体法考察 CGRP及不同浓度的 MDβCD对离体蛙上腭粘膜纤毛运动影响 ,采用在体法及电镜技术考察了 CGRP滴鼻剂对家兔鼻粘膜长期毒性。结果 :降钙素基因相关肽及 4 %以下 MDβCD对纤毛的毒性较低 ,5 % MDβCD对纤毛的毒性较大。CGRP滴鼻剂对家兔鼻粘膜长期毒性较小。结论 :CGRP可以用于鼻腔给药 ,其吸收促进剂初步确定为 4 % MDβCD。更多还原

【Abstract】 Objective:To investigate the toxicity of CGRP and different concentrations of MDβCD on ciliary movement and internal structure of nasal membrane.Methods:Toad palate and rabbit nasal membrane were used as experimental material,physiological saline and hydrochloride ephedrine as negative control.The cilitoxicty of CGRP and different concentrations of MDβCD on ciliary movement were carried out using in vitro and electron microscope technique.Results:The CGRP and MDβCD(concentration lower 4%)had little cilitoxicity to nasal membrane,but obvious cilitoxicity at 5% MDβCD. The CDRP nose drops had little nasal membrane cilitoxicity.Conclusion:CGRP can be used as a drug for the nasal absorption.4% MDβCD wes initially defined as accelerating absorption agent of nasal absorption preparation for CGRP.更多还原