【摘要】 目的:应用微量添加固体滴定和激光散射法测定HA(37℃ )溶解度等温线。方法:滴定物为HA。半导体二极管激光为发射光源,散射光源探测器用于监测超过溶解平衡点出现的沉淀。微量添加固体滴定所引发的沉淀引起散射光源显著且恒定地高于基线,由此判断溶液已处于过饱和状态,该固体滴定总量用于代表溶解度等温线的数据点。结果:HA溶解度等温线(37℃ )由6次滴定合共50个滴定终点构成。与传统方法所得结果比较,本实验所得HA的溶解度约为过往结果的百份之一。结论:微量添加固体滴定和激光散射法利于研究HA的溶解平衡且能得到准确的HA溶解度等温线。更多还原

【Abstract】 Objective:To determine solubility isothermof hydroxyapatite(HA)at37℃using small-increment solid titration and laser-scattering method.Methods:The solid used was HA.Diode laser was the light source and the laser scattering detector was used to monitor the precipitation occurring just after the equilibrium point.The tested solution was identified as supersaturated when a steady but increased laser scattering output was obtained.The end point of the amount of HA added was taken as representing a point on the solubility isotherm.Results:The solubility isothermof HA at37℃was constructed fromsixruns of the titration,includ-ing fifty end points.An apparent solubility of about one-hundredth of that normally obtained was determined.Conclusion:Small-incrementsolidtitrationand laser-scatteringmethod is applicable forthe studyofequilibri-um of HA and has been shown capable of determining the solubility isotherm more precisely.更多还原