【摘要】 目的 :观察一氧化氮合酶抑制剂硝基 -L -精氨酸 (L -NNA)对脑梗死大鼠的影响。方法 :闭塞一侧大脑中动脉造成脑梗死模型 ,检测一氧化氮合酶抑制剂L -NNA对脑梗死大鼠血一氧化氮 (NO)含量、行为障碍、脑梗死范围、脑含水量及脑组织病理学的影响。结果 :L -NNA可显著性缩小脑梗死范围、降低脑梗死大鼠血NO含量和脑组织含水量、减轻其行为障碍和脑组织病理学改变。结论 :L -NNA对脑梗死大鼠脑组织有保护作用更多还原

【Abstract】 Objective: To observe the protective effects of nitric oxide synthase inhibitior (L-NNA) on cerebral ischemia in rats.Methods: Cerebral ischemia was produced in rats by occluding the middle cerebral artery(MCA) on one side. The action damaged in each rat was carefully evaluated ,the range of cerebral infarction,cerebral water content and NO content in rats blood were measured. The histological changes of brain tissue after MCA occluded in rats were also observed. Results: L-NNA could not only obviously improve nervous symptoms but also lessen the infarct size , reduce edema around the necrotic region .Conclusion: L-NNA has the protective effects on cerebral ischemia in rats.更多还原