【摘要】 观察药物消退和稳定动脉粥样硬化的作用并探讨基质金属蛋白酶 1及基质金属蛋白酶组织抑制物 1的表达。对实验性动脉粥样硬化兔 ,分别给予辛伐他汀、丙丁酚和卡托普利治疗 12周。结果发现 ,3种药物均可显著降低血脂 ,以丙丁酚和辛伐他汀效果较强 ;在停止喂胆固醇后 ,自然消退组内中膜进一步增厚 ,3种药物均可显著消退动脉粥样硬化 ;药物治疗组的胶原Ⅰ、基质金属蛋白酶 1及基质金属蛋白酶组织抑制物 1的mRNA表达水平均下降 ,其中丙丁酚组金属蛋白酶 1的表达下降有统计学意义。 3种药物均有消退动脉粥样硬化的作用 ,以辛伐他汀最佳 ;而药物通过减少基质金属蛋白酶 1表达 ,相对减少基质金属蛋白酶 1/基质金属蛋白酶组织抑制物 1的表达比例 ,起到稳定斑块的作用。更多还原

【Abstract】 Aim To study the effects of simvastatin,probucol and captopril on regression and stabilization of atherosclerosis, and to explore the expression of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinases-1 (TIMP-1). Methods 50 rabbits were induced to atherosclerosis by feeding cholesterol and then treated with simvastatin, probucol, captopril respectively for 12 weeks. The tissues of abdominal aorta were studied by reverse transcription polymerase chain reaction (RT-PCR), pathology and immunohistochemistry staining. Results The lipids were decreased in the drug-therapy groups significantly (P<0.05), especially in probucol and simvastatin groups. The atherosclerosis regressed significantly in the drug-therapy groups (P<0.05), and simvastatin had the best result. The expression of mRNA level of collagen Ⅰ, MMP-1 and TIMP-1 was decreased in drug-therapy groups, but was statistically significant only in the probucol group (P<0.01). Conclusion Simvastatin, probucol and captopril could regress the atherosclerosis and stabilize the plaque by reducing the expression of MMP-1.更多还原