【摘要】 目的　观察大蒜素治疗急性脑梗塞临床治疗效果 ,并探讨大蒜素治疗急性脑梗塞的机制。方法　选用发病 3d以内的急性脑梗塞患者 5 5例 ,随机分为大蒜素治疗组及川芎嗪对照组 ,观察临床治疗效果及血清丙二醛 (MDA)含量的动态变化。结果　治疗 2周时大蒜素组及川芎嗪组的有效率分别是为 75 76 %、6 4 6 4 %,治疗 4周时为 86 96 %、76 4 7%,同步比较无差异 (P >0 0 5 ) ;治疗 4周时大蒜素组神经缺损分数的改善是 (10 0 0± 5 5 9) ,川芎嗪组 (6 18± 4 32 ) (P <0 0 5 ) ;急性脑梗塞患者血清MDA含量明显高于健康人 (P <0 0 1) ,大蒜素组MDA含量逐渐下降 ,治疗 3周时明显低于川芎嗪组 (P <0 0 1)。结论　大蒜素对急性脑梗塞具有较好的治疗效果 ,其作用机理是 :大蒜素可有效地清除自由基 ,减轻脑缺血—再灌流损伤。更多还原

【Abstract】 Objective To Observe the curative effect of acute brain infarction (ABI) with allincin and discuss the mechanism of treatment of ABI with allicin. Method Fifty-five cases of ABI, whose illnesses were onset within 3 days, were divided randomly into allicin group and the control group with ligustrazine. The curative effects and dynamic changes of serum MDA content in two groups were observed. Result After 2-week treatment the effective rate in allicin group was 75.76%, control group, 64.64%. After 4-week treatment the effective rate in allicin group was 86.96%, the control group, 76.47%. There was no difference (P>0.05). After 4-week treatment the improvement of grade of nerve injuries in allicin group was 10.00±5.59, in the control group, 6.18±4.32 (P<0.05). Patients of ABI had higher serum MDA content than normal people (P<0.01). After 3-week treatment the cases in allicin group had a gradually decline in MDA content, which obviously lowered than the control group (P<0.01). Conclusion Allicin had good curative effect on ABI. The mechanism of it was to clear away free radical, lighten the injury of cerebral ischemia and reperfusion.更多还原