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小鼠胃排空及小肠推进实验方法的探讨

Investigation of the Experimental Methods for Observing Mouse Gastric Emptying and Small Intestine Propulsion

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【作者】 邢建峰封卫毅侯家玉

【Author】 Xing Jianfeng, Feng Weiyi, Hou Jiayu(Teaching and Research Section of Pharmacology, the College of Traditional Chinese Pharmacy,Beijing University of Traditional Chinese Medicine, Beijing 100102)

【机构】 北京中医药大学中药学院药理教研室北京中医药大学中药学院药理教研室 北京100102北京100102北京100102

【摘要】 目的 改进小鼠胃排空及小肠推进的实验方法。方法 采用营养性半固体黑色糊同时测定小鼠胃排空及小肠推进。结果 本实验方法可同时观察药物对胃排空和小肠推进的影响。结论 本方法能反映药物对胃肠运动的影响 ,节省动物 ,提高实验效率。

【Abstract】 Objective To improve the experimental methods for observing mouse gastric emptying (GE) and small intestine propulsion (SIP). Method The black semisolid nutrient paste was intragastrically given to the mice and GE and SIP were detected at the same time. Results The results showed that improved the effects of drugs on GE and SIP could be observed at the same time. Conclusion The method can well reflect the effects of drugs on GE and SIP, decrease the consumption of the animal and increase the efficiency of experiment.

【关键词】 胃排空肠推进胃复安
【Key words】 Gastric EmptyingIntestine PropulsionMetoclopramide
  • 【文献出处】 北京中医药大学学报 ,Journal of Beijing University of Traditional Chinese Medicine , 编辑部邮箱 ,2003年04期
  • 【分类号】R-331
  • 【被引频次】139
  • 【下载频次】1761
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