【摘要】 目的 :研究老年人非小细胞肺癌 (NSCLC)外科治疗结果及影响预后的因素。方法 :回顾性分析解放军总医院 1980年 1月至 1998年 1月外科手术治疗的 12 4例老年非小细胞肺癌患者的临床资料 ,选取 11个可能对预后有影响的变量输入计算机 ,用SPSS 10 0软件进行分析。Kaplan Meier法计算生存率 ,Log Rank分析进行显著性检验 ,COX模型单因素、多因素预后分析评价预后因素对生存的影响。结果 :全组术后 5年生存率 4 9 4 % ;TNM分期Ⅰ、Ⅱ、ⅢA和ⅢB期术后 5年生存率分别为 72 3%、4 5 5 %、32 4 %及 0 ,组间比较有显著性差异 (P <0 0 1) ;无症状体检发现与有症状诊断肺癌组的 5年生存率分别为 5 8 7%和 4 3 6 % ,有非常显著差异 (P <0 0 0 1)。原发肿瘤大小、局部淋巴结转移及病理类型分别分组 ,各组间 5年生存率也有差异。结论 :老年非小细胞肺癌可获得良好的手术治疗效果 ,TNM分期、病理类型是重要预后因素 ,规律体检有助于发现早期患者改善预后更多还原

【Abstract】 Objective:To study the effect and the prognostic influencing factors in surgical treatment for NSCLC in the elderly Methods:From January 1980 to January 1998,the clinical data of 124 patients who underwent operation for NSCLC in PLA General Hospital were analyzed by Kaplan Meier,Log rank test and COX regressi on model 11 potential prognostic factors were evaluated with SPSS 10 0 softwa re Results: Overall 5 year survival rate was 49 4% The 5 year survival rates of patient with stageⅠ,Ⅱ,ⅢA and ⅢB were 72 3%,37 6%, 32 4%and 0, respectively There were significant differences among different stages ( P <0 01) The 5 year survival rate was 58 7% in group that patie nts were examined without symptom, while 43 6% in group with symptoms There was a significant difference between two groups ( P <0 001) In addition, t here were remarkable differences of 5 year survival rates in groups based on lo cal lymph node metastatic and tumor size and histological type, respectively Conclusion: A good efficacy can be made in elderly patient with NSCLC by surgical treatments TNM staging and histological type are important p rognostic factors in operated NSCLC in elderly Prognosis could be improved by regular examination更多还原