【摘要】 目的 比较文拉法辛缓释剂与帕罗西汀治疗抑郁症的疗效及安全性。方法 96例抑郁症患者,分为文拉法辛组48例,用文拉法辛缓释剂75～150 mg/d;帕罗西汀组48例,用帕罗西汀20～40mg/d,观察期6周,疗效评定用HAMD,HAMA。不良反应评价用TESS、实验室检查及体检。结果 经过6周治疗,文拉法辛组有效率为79.17％,帕罗西汀组为75.00％,2组比较差异无显著性(P>0.05)。同时,文拉法辛缓释剂的抗抑郁作用起效较快,对焦虑症状的疗效优于帕罗西汀(P<0.01)。文拉法辛缓释剂不良反应轻,常见的有:口干、便秘、视力模糊、出汗、食欲减退等。结论 文拉法辛缓释剂是一种安全、有效、抗焦虑疗效好的抗抑郁药。更多还原

【Abstract】 Objective: To compare the efficacy and adverse effect of venlafaxine extended release (XR) versus paroxetine in treatment of depression. Methods:96 patients were divided into venlafaxine (48 patients, using75 - 150 mg/d XR) group and paroxetine (48 patients, using 20 -40 mg/d paroxetine) gruop. The duration of treatment was 6 weeks. HAMD and HAMA were used to evaluate the efficacy. Safety was evaluated with TESS, laboratory test and physical examination. Results:After 6 weeks treatment, the response rate of venlafaxine group and paroxetine group was 79. 17% and 75. 00% respectively. There were no significant differences between the two groups (P > 0.05 ). On the other hand, venlafaxine showed mererapid response and mere effectiveness on anxiety symptom than paroxetine (P < 0. 01). The adverse effects of venlafaxine XR were mild, including dry menth, constipation, blurred vision, sweating and lowappetite. Conclusion: Venlafaxine XR is an effective and safe antidepressant with satisfoutory effect on anxiety symptom.更多还原