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糖尿病大鼠脑干听觉诱发电位波幅间比率的动态变化

Changes of amplitudes to amplitude ratio of brainstem auditory evoked potential in diabetic rats

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【作者】 周卓妍何斯纯林兴会郑辉柏志全王跃春姚平周丽丽

【Author】 ZHOU Zhuo-yan,HE Si-chun,LIN Xing-hui,ZHENG Hui, BAI Zhi-quan,WANG Yue-chun,YAO Ping,ZHOU Li-li (Dept. of Physiology, Medical College, Jinan University, Guangzhou 510632, China)

【机构】 暨南大学医学院生理学教研室暨南大学医学院生理学教研室 广东广州510632广东广州510632广东广州510632

【摘要】 目的 :探讨脑干听觉诱发电位 (BAEP)的波幅间比率在糖尿病大鼠中的动态变化。方法 :采用链脲佐菌素 (STZ)腹腔注射法 ,建立实验性糖尿病 (ED)动物模型。在成模前后按时间顺序连续 10周动态观测BAEP的波幅间比率的变化。结果 :与正常对照组相比 ,ED组大鼠在病程 2周时出现BAEPⅠ、Ⅲ、Ⅳ、Ⅴ波幅增高 ;在病程 4周时出现BAEP各波波幅增高 ;病程 6周时BAEPⅠ、Ⅱ、Ⅲ、Ⅳ波幅增高 ;病程 8~ 10周时BAEPⅠ、Ⅲ、Ⅳ、Ⅴ波幅增高。病程 8周后BAEPV/I波幅比率下降 ;病程 10周后BAEPⅢ与Ⅴ波幅比率降低 ;Ⅴ与Ⅰ、Ⅳ与Ⅰ波幅比率明显降低。结论 :糖尿病大鼠BAEP的波幅和波幅比率有明显变化 ,这有助于糖尿病中枢神经病变的早期诊断。

【Abstract】 Aim: To study the changes of amplitudes to amplitude ratio of brainstem auditory evoked potential (BAEP) in diabetic rats. Methods: Experimental diabetes (ED) rat model was used. Amplitudes and amplitude ratio of BAEP were measured dynamically after ED modeling. Results: The amplitudes of I, Ⅲ, Ⅳ and V of BAEP of ED group were increased after 2 weeks of STZ injection. All waves amplitudes of BAEP were increased after 4 weeks. The amplitudes of I, Ⅱ, Ⅲ and Ⅳ of BAEP were increased after 6 weeks. The amplitudes of I, Ⅲ, Ⅳ and V of BAEP were increased after 8-10 weeks. The amplitude ratio of V/I was lower than control group after 8 weeks. The amplitude ratio of Ⅲ/V was lower; V/I and Ⅳ/I were significantly lower than control group after 10 weeks. Conclusion: There were the earlier period alterations of amplitudes to amplitude ratio of BAEP in ED rats. It might be helpful in the early diagnosis of DCN.

【关键词】 实验性,糖尿病脑干听觉诱发电位波幅大鼠
【Key words】 experimentaldiabetes mellitusBAEPamplituderat
  • 【文献出处】 暨南大学学报(自然科学与医学版) ,Journal of Jinan University(Natural Science & Medicine Edition) , 编辑部邮箱 ,2003年04期
  • 【分类号】R587.1
  • 【下载频次】34
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