【摘要】 采用化学方法以肉碱为底物,合成了外消旋乙酰肉碱,精制后可获得纯度99%以上的乙酰肉碱,收率为96%.利用蜗牛酶(SnailEnzyme)对其进行不对称酯水解反应,发现蜗牛酶对乙酰肉碱具有高度立体选择性,并且可得到光学纯度为98%的乙酰-L-肉碱.更多还原

【Abstract】 Acetyl L carnitine was synthesized from racemic carnitine chloride and acetic acid by chemical means. The purity of the refined product was over 99% and the yield was about 96%. Acetyl L carnitine with 98% ee was obtained by Snail enzyme catalyzing the resolution of racemic acetyl carnitine.更多还原