【摘要】 对RGD(Arg-Gly-Asp)三肽脂质体载药剂型进行研究,确定了薄膜超声法制备脂质体的路线.电子显微镜观察表明,脂质体粒径均匀,为100nm左右,属于小单室脂质体.脂质体中RGD量为2.4～2.5mg/mL,包封率达到70%.脂质体稳定性较好,而且具备pH5.4～6.0的靶向性,可能成为具有较好肿瘤细胞靶向性的脂质体制剂.更多还原

【Abstract】 In this paper, RGD(ArgGlyAsp) liposome formulation as a drug carrier was conducted. A filmultrasonic technique was chosen for preparation of liposome. The observation by electron microscope indicated that the particle diameter of liposome was basically homogenous, being about 100 nm and small vesicles. The content of RGD in liposome is 2.4～2.5 mg/mL with the entrapment efficiency of 70%. RGD liposome prepared by the method used has not only better stability, but also target tropism at pH 5.4～6.0. Therefore, the prepared liposome here may become a kind of RGD formulation with better target tropism to tumor.更多还原