【摘要】 目的:提高对新生儿凝固酶阴性葡萄球菌(CNS)败血症的认识并进行耐药性分析。方法:对120例新生儿CNS败血症的临床特点及药敏试验进行回顾性分析。结果:新生儿CNS败血症缺乏特异性症状和体症,多以黄疸加重或持续不退为主要症状,药敏试验显示CNS对青霉素、红霉素、阿莫西林/棒酸、复方新诺明、头孢唑啉、庆大霉素等多种抗生素产生耐药性,其中对青霉素、红霉素的耐药率达到100％,而对丁胺卡那、第三代头孢抗生素、环丙沙星、亚胺培南、万古霉素的耐药率较低。结论:新生儿败血症病情发展快,临床症状无特异性,对黄疸加重或持续不退的新生儿须给予高度重视,并积极抽送血培养以快速确诊及指导合理用药,在未获得明确原菌之前,可早期选用头孢第三代抗生素,如头孢哌酮、头孢噻肟、头孢他啶,对多重耐药菌株引起的严重感染,可选用环丙沙星,亚胺培南以提高疗效。更多还原

【Abstract】 Objective: To explore clinical feature and drug resistance of neonatal coagulase negative staphylococcus (CNS) septicemia. Method: Clinical data of 120 CNS septicemia patients was studied retrospectively. Results: There were no specific symptoms and signs for CNS septicemia. Progressive or continuous jaundice was the major symptom. Drug sensitivity test showed that CNS was resistant to.penicillin, erythromycin, amoxicillin, SMZ, cefazolin, gentamycin and less resistant to amikacin, the third generation cephalosporins, ciprofloxacin, imipenem,cilastain and vancomycin. Conclusion: Neonatal CNS septicemia tends to have rapid aggravation and has no specific clinical manifestation. Attention should be paid to patients with progressive or continuous jaundice. Blood culture is suggested for diagnosing and use of antibiotics. For case of unclear pathogenic bacteria, the 3rd generation cephalosporins such as cefoperazone, cefotaxime and cefradine may be used early. For multiple drug- resistant bacteria infection, ciprofloxacin and imipeneni may improve therapeutic effect.更多还原