节点文献
3-甲基-1-(2-(1-哌啶基)苯基)丁基胺的合成
Synthesis of 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine
【摘要】 以3-甲基-1(2-哌啶基苯基)丁基酮为原料,采用Leuckart反应合成3-甲基-1.(2-(1-哌啶基)苯基) 丁基胺,最终化合物经核磁共振氢谱及碳谱得到确证.
【Abstract】 The 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine is the key intermediate of Repaglinide. It was synthesized from 3-methyl-1-(2-piperidiny) phenyl)-butylketone through Leuckart reaction. Because the route did not require high pressure, the process was simple and safety. The total yield was 30% . The structures of the intermediate and the target molecule were confirmed by 1H NMR and 13CNMR spectrum.
【关键词】 3-甲基-1-(2-(1-哌啶基)苯基)丁基胺;
Leuckart反应;
合成;
【Key words】 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine; Leuckart reaction; synthesis;
【Key words】 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine; Leuckart reaction; synthesis;
- 【文献出处】 吉林化工学院学报 ,Journal of Jilin Institute of Chemical Technology , 编辑部邮箱 ,2003年04期
- 【分类号】TQ463
- 【被引频次】3
- 【下载频次】195