【摘要】 以1号胃溶空心胶囊为母体,以聚丙烯酸树酯类高分子材料为包衣材料,以愈创木酚甘油醚为模型药物,对不同包衣厚度的结肠溶肠溶胶囊进行了体内外参数研究,结果表明包衣厚度为60～100μm的该肠溶胶囊较为理想.该厚度的胶囊在pH≥7.0的条件下,崩解后所释放出的颗粒在结肠的分布广泛,个体差异小,50%胶囊到达人体回盲部和结肠的时间分别约为4h和5h,达到了结肠靶向给药的设计要求.更多还原

【Abstract】 A colonic delivery capsule is described to deliver orally ingested drugs to the colon and release them at that site by coating with acrylic polymers. The capsules were evaluated in vitro using disintegrating & dissolution (Guaifenesin as a model drug) and in vivo using Xray evidence. It was shown that it is possible to release the major part of drugs (or particles) in the colon by choosing a suitable thickness of coating (60～100?μm) for the capsules. It was also shown that the time of half capsules arrived in the ileum and the colon were about 4 and 5 hours respectively.更多还原