【摘要】 目的　检测SARS患者体内冠状病毒特异性抗体IgG、IgM的含量。方法　抽取 2 2例SARS康复者不同康复时期的血液 ,经病毒灭活后分离血清 ,用ELISA法对SARS病毒特异性抗体IgG、IgM进行检测。结果　IgG类抗体在所有康复者体内都呈阳性 ,且检测到康复 71天的患者该类抗体仍然没有衰减 ;IgM类抗体在康复 5 0天的部分患者 (5 / 2 2 ,2 2 73%)中仍呈阳性 ,而在 6 5天时则全部为阴性。对照组 2 2例 ,两类抗体全部为阴性。结论　可能所有SARS康复者体内都产生了冠状病毒特异的IgG类抗体 ,并且这种抗体可能持续较长时间。更多还原

【Abstract】 Objective Determination of the specific antibodies of IgG and IgM against SARS virus in serum specimens from convalescent SARS patients. Methods The contents of IgG and IgM antibodies against coronavirus were determined with ELISA in the blood of 22 convalescent SARS patients. At the same time, the sera from 22 healthy people were used as negative control. Results The positive rate of specific IgG was 100.0% in convalescent SARS patients (the minimal OD value was 0.477, the maximal OD value was 1.851, the mean value was 1.163), within 71 days of recovery. The positive rate of specific IgM was 22.73% in convalescent patients (5 in 22 samples), and it became negative in all patients after 65 days. On the contrary, the IgG and IgM antibodies were all negative in all 22 healthy people. Conclusion The results indicated that all patients convalescent from SARS could generate specific IgG antibody, which might last for a long time.更多还原