【摘要】 解放军总医院自 1997年开展内镜下注射A型肉毒毒素治疗贲门失弛缓以来 ,至今治疗病人共 165例。治疗前后病人食管下段括约肌 (LES)压力 ( 41 76± 2 2 0 0比 19 14± 11 40mmHg)和LES松弛压力( 14 74±9 41比 8 5 1± 7 85mmHg)差异显著 (P <0 0 0 1)。治疗后随访 12、2 4、3 6个月 ,分别有 87% ( 111/ 12 7)、84% ( 70 / 83 )和 71% ( 2 9/ 41)病人症状未复发。本文总结了 5年应用此技术的经验 ,对提高疗效和推广应用很有一定意义更多还原

【Abstract】 From November 1997 to August 2002, a total of 165 achalasia patients were treated with endoscopic injection of botulinum toxin A into the gastric cardia. The results showed that the lower esophageal sphincter (LES) pressure (41.76±22.00 vs 19.14±11.40 mmHg) and LES relax pressure (14.74±9.41 vs 8.51±7.85mmHg) were decreased significantly (both P<0.001) after the treatment. Eighty seven percent (111/127), 84% (70/83), and 71%(29/41) of patients were still in clinical remission after 12, 24 and 36 months follow-up respectively. In the article, we summarized the experience in using this technique for 5 years. The results seem to be encouraging.更多还原