【摘要】 目的　分析不同SARS抗病毒治疗方法的效果 ,为制定SARS抗病毒治疗方案提供参考。方法　采用临床流行病学回顾研究 ,使用SPSS11.0软件分析我院SARS患者的住院病历 ,分析选择不同抗病毒治疗药物治疗SARS的T细胞亚群、血象、肝肾功能变化及临床效果。结果　本文研究发现 ,利巴韦林治疗病死率为 18.0 3% ;干扰素组T细胞亚群下降值最低 ,但治愈率为 10 0 % ,与利巴韦林组比较 (P <0 .0 0 1)统计学有极显著性差异 ,并有延长T细胞亚群下降至最低值时间的趋势 (P >0 .0 5 ) ;干扰素与利巴韦林联合治疗可延长T细胞亚群下降至最低值的时间 ,CD3 与利巴韦林组比较 (P <0 .0 5 )统计学有显著性差异 ,病死率为 6 .0 6 % ,与利巴韦林组比较 (P <0 .0 5 )统计学有显著性差异 ,并低于文献报道水平 (6 .5 % )。干扰素组对SARS患者血象及肝肾功能的影响最小 ,各组与利巴韦林组比较 (P >0 .0 5 )统计学无显著性差异。结论　干扰素或干扰素联合利巴韦林抗病毒治疗效果优于单独使用利巴韦林的效果。干扰素抗病毒治疗效果最好。更多还原

【Abstract】 Aim To analysis the effect of different SARS anti-virus therapy and supply the reference for SARS treatment project.Methods Based on the principle of Clinical Epidemiology review.According to the SARS patients’ cases,analysis the changes of the T cell subset,liver and kidney function blood routine and clinical effects by the different anti-virus drugs therapy using SPSS11.0 software.Results The mortality by the therapy of Ribavirin is 18.03%.T cell subset descent degree by the therapy of Interferon is the lest,but the mortality is 0%(P<0.001) and the tendency of the descent speed of T cell subset is delayed (P>0.05).The descent speed of CD 3 by the therapy of Ribavirin and Interferon combined is delayed (P<0.05),the mortality is 6.06% (P<0.05).The influence to blood routine,liver and kidney function by the therapy of Interferon is the lest.Conclusion The effect of Interferon and the effect of the Ribavirin and Interferon combined are better than that of Ribavirin.The effect of Interferon is the best.更多还原