节点文献
麝香保心分散片的制备和人参总皂苷的体外溶出度研究
Studies on the Dissolution of Total Ginsenoside in vitro and Preparation of Heart-protecting Musk Dispersible Tablets
【摘要】 目的 制备麝香保心分散片 ,考察人参总皂苷的体外溶出度。方法 以PVPP为崩解剂、MCC为填充剂、CMC Ca为溶胀性辅料、1%HPMC水溶液为粘合剂 ,制备麝香保心分散片 ;采用比色法以人参总皂苷为测定指标 ,考察其体外溶出度。结果与结论 按最佳工艺制备的麝香保心分散片在 (2 0± 1)℃水中于 15s内可完全崩解且分散均匀 ,其指标性成分人参总皂苷的溶出速率明显高于麝香保心丸
【Abstract】 Aim To prepare heart protecting musk dispersible tablets and investigate the dissolution of total ginsenoside in vitro.Methods Heart protecting musk dispersible tablets were prepared by selecting PVPP as disintegration,MCC as filler,CMC Ca as sweller and 1% HPMC solution as adhesive agent.The dissolution of total ginsenoside of heart protecting musk dispersible tablets was determined by colourimetry.Results and conclusion Heart protecting musk dispersible tablets formulated with the optimum techniques disintegrated and dispersed well distributedly within 15 seconds in (20±1)℃ water.The dissolution rate of total ginsenoside of heart protecting musk dispersible tablets was obviously faster than that of heart protecting musk pills.
【Key words】 Heart protecting musk dispersible tablets； Total ginsenoside； Dissolution in vitro；
- 【文献出处】 解放军药学学报 ,Pharmaceutical Journal of Chinese People’s Liberation Army , 编辑部邮箱 ,2003年01期
- 【分类号】R286
- 【被引频次】23
- 【下载频次】277