【摘要】 探讨失血性休克复苏时肺组织中一氧化氮合酶 (NOS)活性、一氧化氮 (NO)含量的变化及牛磺酸对其的影响。新西兰种兔 2 4只随机分为三组 (n =8) :对照组、休克复苏组、牛磺酸治疗组。采用失血性休克复苏动物模型。结果发现 :休克复苏 3h肺湿重 肺干重、肺水含量、肺通透指数 (LPI)、肺泡灌洗液 (PALF)中蛋白含量、肺组织中NOS活性、NO含量均升高 (均P <0 0 1)。同时 ,血浆中NOS、LDH活性及NO含量均有显著升高 (均P <0 0 1)。预先给予牛磺酸 (静脉注射 ,4 0mg kg体重 )可显著缓解上述变化 (均P <0 0 1)。提示失血性休克复苏时NOS的激活和NO的大量释放 ,对休克复苏所致肺损伤的发生发展起重要作用 ,牛磺酸对这种肺损伤具有明显的保护作用更多还原

【Abstract】 To investigate the changes of nitric oxide synthase (NOS)activity and nitric oxide products( NO 2 -/NO 3 -)content in lung tissue during shock resuscitation as well as the effect of taurine. Twenty four rabbits were randomly divided into 3 groups(n=8): control group, shock group and taurine group. Result showed: In shock group,lung wet/dry weight, water content, permeability index,and protein content in BALF, the activity of NOS and the content of NO 2 -/NO 3 - in lung homogenate obviously increased 3 hours after resuscitation( P <0.01). Meanwhile,the activities of NOS and LDH, the content of NO 2 -/NO 3 - in plasma increased significantly ( P <0.01). All the changes mentioned above were attenuated by intravenous injection of taurine(40mg/kg)( P <0.01). It suggest that the activation of NOS and NO release played an important role in lung injury induced by shock resuscitation and taurine has significant protective effect.更多还原