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Peptide 68-88 of apocytochromec plays a crucial role in its insertion into membrane and binding to mitochondria

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【Author】 WANG Xiaoping, HAN Xuehai& YANG Fuyu National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Correspondence should be addressed to Yang Fuyu (email: yangfy@sun5.ibp.ac.cn)

【机构】 National Laboratory of Biomacromolecules； Institute of Biophysics； Chinese Academy of Sciences； Chinese Academy of Sciences Beijing 100101； China； Beijing 100101； China；

【Abstract】 Apocytochrome c (Apocyt. c) is the precursor of cytochrome c. It is synthesized in the cytosol and posttranslationally imported into mitochondria. In order to determine the crucial se-quence in apocyt. c translocation, deleted mutant and chemically synthesized peptides with differ-ent length were used. Obtained results showed that sequence 68-88 of apocyt. c plays a critical role in its insertion into membrane and binding to mitochondria.更多还原

【关键词】 apocyt. c； crucial peptide； insertion into membrane； binding to mitochondria.；
【Key words】 apocyt. c； crucial peptide； insertion into membrane； binding to mitochondria.；

【基金】 the National Natural Science Foundation of China (Grant No. 39730130) and the Chinese Academy of Sciences.

【文献出处】 Science in China(Series C:Life Sciences) ,中国科学(C辑:生命科学)(英文版) , 编辑部邮箱 ,2003年01期

【分类号】Q26
【下载频次】33

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