【摘要】 目的　探索治疗难治性及复发性急性白血病的有效化疗方案。 方法　5 8例难治性复发性急性白血病患者 ,用MVA方案 8天疗法 ,即米托蒽酮 (Mx) 5～ 10mg/ (m2 .d) ,第 1～ 3天 ,静注 ,据病情可在第 8天再给 5～ 10mg/ (m2 .d) ,足叶乙甙 (VP - 16 ) 10 0mg/ (m2 .d) ,第 4～ 8天用 ,静点 (<2h)。阿糖胞苷 (Ara -c) 2 0 0mg/ (m2 .d) ,第 1～ 8天用 ,静点。 结果　CR 2 8例 ,PR 17例 ,总有效率 77 6 %。未出现严重骨髓抑制 ,大部分病人有恶心 ,呕吐等胃肠道反应。 结论　MVA方案治疗难治性复发性急性白血病收到较满意效果更多还原

【Abstract】 Objective To explore effective chemotherapy regimens for relapsing and refractary leukemia. Methods 58 patients with relapsing or refractory acute leukema were treated with MVA regimen for 8 days:MX 5～10mg/(m 2.d 1～3 ),iv if needed adding 5～10mg/(m 2.d8);VP16 100mg/(m 2.d),d4～8 iv(<2h);Ara-C 200mg/(m 2.d) d1～8 ivgtt.Results There were 28 cases of complete response and 17 cases of partial response.The total effective rate was 77.6%.There was no severe myelosuppression,and most patients had gastrointestinal tract reaction such as nausea,vomitting.Conclusion The MVA is effective to treat relapsing or refractory acute leukemia.更多还原