【摘要】 目的观察模拟失重大鼠血脂、红细胞膜流动性、红细胞变形性和血管内皮细胞的变化以及螺旋藻对其影响。方法 30只雄性SD大鼠随机分为 3组 (每组 1 0只 ) :A组为地面自由活动组 ;B组和C组为模拟失重组 ,其中A、B两组饲喂普通饲料 ,C组饲喂普通饲料 + 5 % (W/W)螺旋藻全粉 ,连续饲喂 3周。观察大鼠血脂浓度、红细胞膜的流动性、红细胞膜的变形性以及脱落循环上皮细胞数量的变化。结果B组大鼠血总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL C)、甘油三酯 (TG)水平和HDL C/TC以及红细胞变形性 (IDmax)和红细胞膜流动性降低 ,动脉粥样硬化指数 (AI)和低密度脂蛋白胆固醇 (LDL C) /HDL C比值增高 ,血管脱落的内皮细胞增多。C组与B组相比 ,TC、HDL C和红细胞变形性以及红细胞膜流动性增加 ,LDL C/HDL C比值AI降低以及脱落循环内皮细胞减少。结论螺旋藻能改善模拟失重条件下大鼠的心血管以及红细胞膜的生理状况和调节血脂水平。更多还原

【Abstract】 Objective To study the changes of erythrocyte membrane fluidity,serum lipid and vascular endothelial cell caused by simulated weightlessness in rats and the beneficial effect of spirulina. Method Thirty male SD rats were divided into 3 groups : free control group(group A) and two simulated weightlessness groups(groups B,C).Rats in group A and B were fed with normal forage ,and the rats in group C were fed with normal forage supplemented with 5% (W/W) spirulina. Water was taken ad libitum. Result Levels of serum CHO,HDL,TG, HDL C/CHO and erythrocyte membrane fluidity decreased significantly, and number of vascular endothelial cells in plasma increased markedly in group B as compared with those in group A;The ratio of LDL C/HDL C,and atherosclerosis index (AI) decreased, number of vascular endothelial cells significantly lowered; level of CHO、HDL C and value of the ID max of plasma as well as erythrocyte membrane fluidity remarkedly increased in group C compared with those in group B.Conclusion Spirulina can improve the physiological conditions of erythrocyte membrane fluidity,serum lipid and vascular endothelial cell caused by simulated weightlessness in rats.更多还原